Хаффман, Джон: биография
- Huffman, J. W.; Miller, J. R. A.; Liddle, J.; Yu, S.; Thomas, B. F.; Wiley, J. L.; Martin, B. R. Structure-activity relationships for 1',1'-dimethylalkyl-?8-tetrahydrocannabinols. Bioorg. Med. Chem. 2003, 11. 1397—1410
- Huffman, J. W.; Mabon, R.; Wu, M.-J.; Lu, J.; Hart, R.; Hurst, D. P.; Reggio, P. H.; Wiley, J. L.; Martin, B. R. 3-Indolyl-1-naphthylmethanes: new cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB1 cannabinoid receptor, Bioorg. Med. Chem. 2003, 11, 539—549.
- Huffman, J. W.; Bushell, S. M.; Miller, J. R. A.; Wiley, J. L.; Martin, B. R. 1-Methoxy-, 1-Deoxy-11-hydroxy- and 11-hydroxy-1-methoxy-?8-tetrahydrocannabinols: new selective ligands for the CB2 receptor. Bioorg. Med. Chem. 2002, 10, 4119-4129.
- Sanchez, C., M.L. de Ceballos, T.G. del Pulgar, D. Rueda, C. Corbacho, G. Velasco, I. Galve-Roperh, J.W. Huffman, S.R.Y. Cajal, and M. Guzman, Inhibition of glioma growth in vivo by selective activation of the CB2 cannabinoid receptor. Cancer Research, 2001. 61(15): p. 5784-5789.
- Liddle, J. and J.W. Huffman, Enantioselective synthesis of 11-hydroxy-(1 ' S,2 ' R)- dimethylheptyl-Delta(8)-THC, a very potent CB1 agonist. Tetrahedron, 2001. 57(36): p. 7607-7612.
- Huffman, J.W., J.Z. Lu, G. Hynd, J.L. Wiley, and B.R. Martin, A pyridone analogue of traditional cannabinoids. A new class of selective ligands for the CB2 receptor. Bioorganic & Medicinal Chemistry, 2001. 9(11): p. 2863-2870.
- Huffman, J.W., J.Z. Lu, D. Dai, A. Kitaygorodskiy, J.L. Wiley, and B.R. Martin, Synthesis and pharmacology of a hybrid cannabinoid. Bioorganic & Medicinal Chemistry, 2000. 8(2): p. 439-447.
- Huffman, J.W., The search for selective ligands for the CB2 receptor. Current Pharmaceutical Design, 2000. 6(13): p. 1323-1337.
- Baker, D., G. Pryce, J.L. Croxford, P. Brown, R.G. Pertwee, J.W. Huffman, and L. Layward, Cannabinoids control spasticity and tremor in a multiple sclerosis model. Nature, 2000. 404(6773): p. 84-87.
- Aung, M.M., G. Griffin, J.W. Huffman, M.J. Wu, C. Keel, B. Yang, V.M. Showalter, M.E. Abood, and B.R. Martin, Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding. Drug and Alcohol Dependence, 2000. 60(2): p. 133-140.
- Martin, B.R., R. Jefferson, R. Winckler, J.L. Wiley, J.W. Huffman, P.J. Crocker, B. Saha, and R.K. Razdan, Manipulation of the tetrahydrocannabinol side chain delineates agonists, partial agonists, and antagonists. Journal of Pharmacology and Experimental Therapeutics, 1999. 290(3): p. 1065-1079.
- Huffman, J.W., J. Liddle, S. Yu, M.M. Aung, M.E. Abood, J.L. Wiley, and B.R. Martin, 3-(1 ',1 '-dimethylbutyl)-1-deoxy-Delta(8)-THC and related compounds: Synthesis of selective ligands for the CB2 receptor. Bioorganic & Medicinal Chemistry, 1999. 7(12): p. 2905-2914.
- Chin, C.N., J.W. Murphy, J.W. Huffman, and D.A. Kendall, The third transmembrane helix of the cannabinoid receptor plays a role in the selectivity of aminoalkylindoles for CB2, peripheral cannabinoid receptor. Journal of Pharmacology and Experimental Therapeutics, 1999. 291(2): p. 837-844.
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